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These multifaceted biological activities position bromelain as a promising therapeutic agent for conditions associated with excessive inflammation and oxidative stress, including arthritis, inflammatory bowel disease, certain cancers, sinusitis, rhinosinusitis, respiratory disorders, cardiovascular diseases, and skin wounds, as demonstrated by preclinical studies using experimental models such as rodents and cell cultures, which have reported protective effects on various organs, notably the liver, lungs, and gastrointestinal tract 17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39

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Pseudomonas aeruginosa anthranilyl-CoA synthetase (PqsA) is another ANL family member that has been identified as a potential antibacterial target [153] (Fig